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Manufacturing: A Peptide-Specific Bottleneck From a bioprocessing perspective, GLP-1 analogs present unique challenges due to their peptide nature: Peptide Stability: GLP-1 analogs are prone to degradation due to their sensitivity to temperate, pH and enzymatic activity

The formulation pairs sodium chenodeoxycholate (a compound that improves intestinal absorption) with propyl gallate, an antioxidant that stabilizes the drug

Conversely, differences in glycemic control were significant only for those who were diagnosed with both obesity and T2DM, but not for those with either obesity alone or T2DM alone

DOI: 10.3390/cells10102759 [Google Scholar] Kisseleva T, Brenner D