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This may be due to carnitine's ability to keep blood glucose levels low even following a large carbohydrate meal

In a study conducted in nine healthy young volunteers, the rise of homocysteine during the postprandial period (after a meal) was found to be greater with marginal vitamin B 6 deficiency (mean plasma PLP level of 19 nmol/L) as compared to vitamin B 6 sufficiency (mean PLP level of 49 nmol/L) (36)

Therefore, when semaglutide is used for weight management, administer with caution in patients with depression and avoid use in patients with a history of suicide attempts or active suicidal ideation

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