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This can show up as symptoms such as delayed growth and development (failure to thrive), regression in neuromotor skills (such as losing the ability to roll over or grasp objects), failure to maintain eye contact (even in an infant who previous could do so), general muscle weakness, lethargy, excessive sleepiness, feeding difficulties, and even brain shrinkage

multiple mono-ubiquitination, in which multiple lysine residues of a substrate protein are tagged by several mono-ubiquitin molecules at the same time

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