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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction

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In the landmark UK Prospective Diabetes Study (UKPDS) , metformin use in overweight patients with type 2 diabetes significantly reduced diabetes-related endpoints, myocardial infarction, and all-cause mortality compared with conventional therapy, effects that persisted on long-term follow-up (Lamanna et al., 2011