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It has been reported that AC inhibited the proliferation of HT29 human colon cancer cells in a dose-dependent manner with an IC 50 of approximately 50 g/mL, where it exhibited strong anti-metastatic and anti-invasive effects by inhibiting the Rac family small GTPase 1 (Rac-1), hypoxia-inducible factor-1 alpha (HIF-1), and zinc finger E-box-binding homeobox 1 (Zeb-1) pathways (Seyfi et al

Non-anesthetic procedures, while not shown to be safer or as thorough as anesthetized cleaning, 117 may be more appropriate in animals for which anesthesia may pose increased risk

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This observed increase may reflect the high prevalence of metabolic comorbidities among patients with PCOS, rather than expanded prescribing of GLP-1s specifically for PCOS