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Semaglutide, a GLP-1 receptor agonist, is commonly used for weight management and to help control blood sugar levels in individuals with type 2 diabetes

an explanation may be that the generation of hydrogen peroxide by the polymorphonuclear neutrophiles might cause a decrease in the quantity of reduced glutathione, whose function is to eliminate, from the red cell, the accumulated metabolites that oxidate the sulfhydryl groups formed by the oxidative stress and therefore decreasing the protective capacity of the cell

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Current evidence supports continuous use for 812 weeks followed by a 4-week washout period to assess sustained metabolic improvements and prevent receptor downregulation