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In the STEP 1 trial extension phase, participants who discontinued semaglutide regained approximately two-thirds of their lost weight within one year

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The researchers argued, The increased risk associated with short-acting analogs needs further studies to validate these findings. The possible protective effect of GLP-1 receptor agonists against AMD may be primarily attributed to their ability to mitigate chronic retinal inflammation and oxidative stress, which are pivotal in the pathogenesis of AMD, the authors explained in their paper

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Recently, a GLS1 selective inhibitor, CB-839 (telaglenastat), tested in preclinical trials showed no significant side effects and, therefore, was moved forward into clinical trials

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