Methods: In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the height in meters) of 30 or greater (27 in persons with 1 weight-related coexisting condition), who did not have diabetes, and randomly assigned them, in a 2:1 ratio, to 68 weeks of treatment with once-weekly subcutaneous semaglutide (at a dose of 2.4 mg) or placebo, plus lifestyle intervention
Standard dosing and titration schedules are often suitable across most CKD stages because these medications are not primarily metabolized by the kidneys , meaning reduced kidney function has minimal impact on how the body processes them
Advances in experimental medicine and biology , 1307 , 171192
Alexis Pedrick: This is Laura Dawes, a historian of science and author of Childhood Obesity in America: An Epidemic. Laura Dawes: So in the way that genetics is the cool area now, or your microbiome, in the 1890s, endocrinology, that was it, that was the frontier of medicine
