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Nat Rev Mol Cell Biol (2020) 21:67895

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis of schizophrenia

Consistent with the findings that intestinal AMPK, which mediates NAMPT activation, is impaired in glucose intolerance, HFD-induced obesity, and aging downregulates the major NAD + -generating enzymes, including NAMPT, and reduces intestinal NAD + levels [31,99,100]