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All the studies included people with overweight and obesity and 21 studies enrolled participants with prediabetes or type 2 diabetes

3,4 Polypharmacy is generally defined as the use of five or more medications and often occurs because of a prescribing cascade, which means the culprit medication causes an ADE that is mistaken for a new medical condition for which a subsequent medication is initiated as treatment

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QC samples were analysed at the beginning, middle, and end of each batch to gauge between-batch reproducibility, with the relative standard deviation (RSD%) measured for each analyte