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Targets 12 , 14971507 (2008)

33 Non-specific cysteine transporters While influx transporters are the main means by which cells acquire cystine, cysteine can also be taken up from the extracellular milieu into cells directly by excitatory amino acid transporter 3 (EAAT3) and the alanine-serine cysteine transporters 1 and 2 (ASCT1/2), all of which are known to be overexpressed in different cancer types 34 (Table 1)

Challenges remain in deciphering causal relationships, accounting for inter-individual variability, and ensuring reproducibility in therapeutic outcomes

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