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Description

The increased sympathetic tone may explain a known GLP-1RA class effect of a modest but significant increase in heart rate, the clinical consequences of which are undetermined

Obesity trials (STEP and SCALE programs) were not designed to evaluate renal outcomes

All current adult use of sermorelin is off-label, supplied through licensed compounding pharmacies

More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings