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Chronic stress, elevated glucocorticoid exposure, and neuroinflammatory signaling suppress the proliferation, differentiation, and survival of neural progenitor cells, leading to reduced hippocampal volume and functional impairments commonly observed in major depressive disorder (42)

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Studies have demonstrated that tocotrienol supplementation at a dosage of 150 mg/day notably elevated erythrocytic SOD and GPx activity in healthy older females after 6 months of treatment compared to the control group