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However, in subsequent investigations in rodent models of depression, (2R,6R)-hydroxynorketamine did not exhibit antidepressant-like effects and increased aggressive behavior (Yang et al., 2019)

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Os sintomas incluem dificuldade de concentrao, lapsos de memria, irritabilidade, dificuldade de tomar decises e sensao de nevoeiro mental

216 In addition, PRMT4-catalyzed asymmetric dimethylarginine (ADMA) has been reported to bind to NOS as a ligand, leading to NOS dysfunction, resulting in decreased cerebral blood flow and aggravating AD, which can be reversed by inhibition of PRMT4