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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

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Because there is no combination-level trial, this timeline is a synthesis of the individual-peptide literature and the protocols own structure treat it as a framework for observation, not a guarantee

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