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[PubMed: 37093254] Coskun T, et al

And adding insult to injury, many of these slow or non-responders still grapple with unpleasant side effects like nausea or digestive issues, often just from trying to titrate up to those therapeutic doses, without reaping the weight loss benefits

Yet, a randomized, double-blind, placebo-controlled trial in 215 men (35-55 years old) found that daily supplementation with B vitamins (at 3 to 13 times the current RDA, except for folic acid, which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), zinc (10 mg/day), and magnesium (100 mg/day) for 33 days had no effect on measured performance of executive functions, including the Stroop color-word test, the peg-and-ball task, and the Wisconsin card-sorting task (134)

High-throughput compound screens may yield new therapeutics