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When a cardiologist's primary clinical mandate is preventing heart attacks and strokes, and a drug demonstrates 20% reduction in major cardiovascular events, that drug becomes a cardiovascular medicine rather than a metabolic medicine

A limited number of clinical trials and case reports demonstrated that 1 h of compression with 193 mbar in the hyperbaric chamber, corresponding to a descent of 2250 m, lead to a short term improvement in symptoms of AMS but had no longterm beneficial effect

Each plays an important role: B1 (Thiamine)

En la prctica, esto se traduce en unos 10-12 aos de exclusividad comercial efectiva una vez aprobado el medicamento