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In the contrary, an improvement in hyperpigmented areas in glutathione gel with noisome treated right side was reported in the form of decreased shades of pigmentary network in cases of epidermal melasma and decreased irregularity of pigmentary network, decreased number of granules in mixed melasma, this agrees with Javed and colleagues , who used dermoscopy and Woods light in their studies

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thus, minimal edema accompanies minimal separation of the muscle from bone (Figure 13)