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& Cohn, Z
In the second case, even though the rats are fasted, the rapid reuptake of cysteine, glycine, and glutamate by the liver cells insures that the synthesis of GSH declines relatively slowly and therefore the observed half-life is long
However, it is worth noting that iron accumulation at the hypothalamic-pituitary level may impair Gonadotropin-releasing hormone neurons and/or pituitary gonadotroph cells and lead to hypogonadotropic hypogonadism, which is characterized by low levels of gonadotropins (FSH and LH) and testosterone, thus indirectly affecting testicular function [67, 68]
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