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CD4+ T cell counts begin to rise as expected in response to therapy, but patients who develop IRIS will additionally experience an excessive inflammatory response to prior infections, typically within 6 months of initiating HAART

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We know that B12 recovery from bile would be a problem but this only contributes 5mcg to the picture, so I think its an open question

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Left untreated, a severe deficiency can cause permanent nerve damage

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