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The following additional adverse reactions have been reported rarely: vitiligo depigmentation, small depigmented spots, hypertrichosis, reddening (signs of keratosis pilaris), and exacerbation of recurrent herpes viral infection (i.e., herpes labialis)

Moreover, the variants exhibited Flex ddG values ranging from 0.8 kcal/mol to 2.4 kcal/mol, implying a limited effect on binding affinity, which might be attributed to variants being distant from protein binding interfaces (Fig

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The compound appears well-tolerated in animals at doses well above those producing metabolic effects