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Importantly, supplementation can **increase** measurable NAD+ metabolism: in a 2018 randomized, placebo-controlled crossover trial published in Nature Communications by Martens and colleagues at the University of Colorado Boulder (24 healthy middle-aged and older adults), 1,000 mg/day of the NAD+ precursor nicotinamide riboside (500 mg, twice daily) elevated NAD+ in blood cells by roughly 60% versus placebo over 6 weeks, with no serious adverse events reported
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Guarneri F, Bertino L, Pioggia G, Casciaro M, Gangemi S
Continuous daily dosing beyond 72 hours may trigger c-Met receptor downregulation and internalization, reducing the compound's effectivenessa concern that favors intermittent protocols for extended research timelines
Both providers screen for personal or family history of medullary thyroid carcinoma or MEN-2, which are contraindications listed in the prescribing information
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