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There have been extensive reviews of the relationship between NAD + and the 9 aging hallmarks, namely genomic instability [[42], [43], [44], [45]], telomere attrition [46], epigenetic alterations [47], loss of proteostasis [44,[48], [49], [50]], deregulated nutrient sensing [[51], [52], [53]], mitochondrial dysfunction [54,55], cellular senescence [55,56], stem cell exhaustion [[57], [58], [59], [60]], and altered intercellular communication [[60], [61], [62], [63]]

2013;88(6):544-551 Posted May 7, 2013

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