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Preclinical data on the mechanisms of potential sex differences in the endogenous GLP-1 system as well as the therapeutic effect of GLP-1 analogs, focusing on the effects of the drugs on the brain and behavior relating to appetite and metabolism, are highlighted

The SUMMIT trial demonstrated that tirzepatide reduced cardiovascular events by 18% in people with obesity and established heart disease, even in patients without diabetes

Mitochondrial function in liver cells is resistant to perturbations in NAD(+) salvage capacity

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