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Ghrelin, secreted by EECs in the stomach, is an orexigenic (appetite stimulating) peptide, and cholecystokinin primarily secreted from the proximal small intestine by I cells in response to fat and protein promotes the release of bile into the duodenum, inhibits gastric emptying, and stimulates exocrine pancreatic and gastric acid secretion 87

After losing about 35 pounds over the previous year through diet changes, I was left with loose skin that exercise alone wasnt fixing

51, 52, 53 In the small intestine, GPBAR1/TGR5 activation could favorably modulate insulin sensitivity and glucose metabolism through stimulating the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) by ileal enteroendocrine L cells

doi:10.1007/s11684-020-0786-5 35