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If high plasma or serum vitamin B12 would be causally related to cancer, it is expected that treatment with vitamin B12 (that raises plasma vitamin B12) would also cause cancer

The limited controlled trial data showed modest effects at best, which is a long way from establishing clinical usefulness

For bodybuilders, this may be relevant when inflammation contributes to pain, stiffness, swelling, or reduced training quality

This also depends on how your body reacts to the medication, but clinical trials showed that after 24 weeks (around six months), the average participant on higher doses of retatrutide lost close to 18% of their body weight