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However, no significant effect was observed on the rates of heart failure or myocardial reinfarction (DiNicolantonio et al

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Visible results typically appear after 6 to 8 weeks of consistent use.

However, it is not possible to directly extrapolate in vitro results to in vivo results, but there is a great variability of enzymatic activity (lato sensu) among, for example, microorganism strains and animal species, including humans [139-142]