Subacute combined degeneration of the spinal cord , a serious complication of untreated B12 deficiency described in NHS and British Society for Haematology guidance, affects both the dorsal columns and corticospinal tracts
In the long-term toxicity experiment, continuous injection of AOD 9604 (10 mg/kg) for 8 weeks did not cause abnormal liver and kidney functions or fluctuations in blood glucose, providing a safety basis for its further research and application
598 FTH1 knockdown in neurons significantly inhibits cell viability and causes mitochondrial dysfunction, while overexpression of FTH1 impairs ferritinophagy, downregulates the expression of LC3 and NCOA4, and finally inhibits cell ferroptosis
doi: 10.3389/ftox.2024.1515850 Received 23 October 2024 Accepted 31 December 2024 Published 20 January 2025 Volume 6 - 2024 Edited by Yong Ho Kim, United States Environmental Protection Agency (EPA), United States Reviewed by Colette Miller, United States Environmental Protection Agency (EPA), United States Meghan Rebuli, University of North Carolina at Chapel Hill, United States Updates Copyright 2025 Granata, Morosini, Valerii, Fagiolino, Sangiorgi, Ghini, Spisni, Vivarelli, Fairclough, Paolini and Canistro
