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A report from the Institute of Medicine found that raising the smoking age to 21 would prevent 223,000 premature deaths, result in 50,000 fewer deaths from lung cancer and 4.2 million fewer years of lives lost for those born between 2000 and 2019

Longitudinal cohort and population-based studies show that elevated inflammatory markers such as IL-6 and CRP predict physical decline and mortality in aging populations, supporting the role of sustained inflammation in immune aging ( Innate immune cells also undergo age-associated functional changes