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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

Dimercaptosuccinic acid (DMSA) has been recommended by poison control centers around the world for the treatment of lead poisoning in children

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However, despite its promising mechanisms, AOD-9604 is not FDA-approved for medical use