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For instance, as Retatrutide facilitates significant weight loss, MOTS-c could theoretically ensure that the metabolic machinery within cells is functioning optimally to adapt to the new metabolic state, potentially improving the quality of weight loss or metabolic adaptation

doi:10.3390/nano11030743

Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits

doi: 10.3181/0037972720743786 155 JinJHashizumeT