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Approximately 12%, 28%, and 49% of linagliptin when administered as supraclinical intravenous doses to Wistar rats was eliminated as the unchanged parent compound via gut, urine, and bile, respectively

To remove DMF from water, use: (a) vacuum distillation (azeotrope), (b) adsorption on activated carbon, or (c) salting-out with high concentrations of inorganic salt (KCl, KCO) followed by careful layer separation