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Angioedema swelling of deeper skin layers, particularly around the eyes, lips, tongue, or throatrepresents a more concerning manifestation that requires urgent medical assessment

This glucose-lowering effect contributes to weight loss but also carries hypoglycemia risk that requires careful provider monitoring and patient awareness

[DOI] [PubMed] [Google Scholar] 12.Ghodsi M., Larijani B., Keshtkar A.A., Nasli-Esfahani E., Alatab S., Mohajeri-Tehrani M.R

while, on the other hand, the excessive release of mitochondrial reactive oxygen species (mtROS) degrades tight junction proteins and the basement membrane by activating matrix metalloproteinases (MMPs) and inflammatory signaling pathways