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Phenylbutazone showed the most promising results, with low EC 50 values for both the glutathione (80 nM) and senescence (50 nM) assays

The agency noted 32 adverse event reports between 2019 and 2024including erectile dysfunction, depression, and suicidal ideationand emphasized that topical application does not eliminate systemic absorption

Moreover, these treatments do not reverse neurobiological deterioration caused by prolonged stress, neuroinflammation, hormonal imbalance, or oxidative stresskey contributors to chronic insomnia