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The semaglutide plateau phenomenon also deserves mention here

In patients with type 2 diabetes, the mean population-PK estimated steady-state concentrations following once-weekly subcutaneous administration of 0.5 mg and 1 mg semaglutide were approximately 65 ng/mL and 123 ng/mL, respectively

For T2D-trial eligibility, the corresponding estimates were 4.5% (M) versus 3.8% (F) in Non-Asian US, 1.8% versus 1.3% in Asian US, and 2.6% versus 1.6% in Korean adults