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Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to exert pleiotropic effects, including stimulation of the activity of the hypothalamic-pituitary-adrenal axis

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Studies on these medications highlight factors that negatively impact nutritional health and well-being, including loss of lean body weight (muscle mass), gastrointestinal side effects, reduced intake of protein, fiber and essential micronutrients, and significant decreases in daily calorie intake by as much as 40-50%

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