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About Avexitide Avexitide is an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist that has been evaluated in five Phase 1 and Phase 2 clinical trials for post-bariatric hypoglycemia (PBH) and has also been studied in congenital hyperinsulinism (HI)

The NHS is expected to offer Mounjaro starting in 2025 , initially for those with a BMI over 35 and weight-related health problems

GLP-1 is made in the gut and helps: Trigger insulin release Lower glucagon levels (which raise blood sugar) Slow digestion Increase feelings of fullness GIP is made in the small intestine and helps: Stimulate insulin release after eating Regulate blood sugar and energy Influence appetite and fat storage These medications mimic the actions of the bodys natural GLP-1 and/or GIP hormones

Xu, R., Huang, F., Zhang, S., Lv, Y., & Liu, Q