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14 Patients typically have normal amounts of dissolved O2 in their blood (pO 2 ) despite the low O2 saturation on pulse oximetry

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Moreover, both in vivo and in vitro whole-cell patch-clamp recordings have shown that acetaminophen metabolite AM404 directly inhibits excitatory synaptic transmission via TRPV1 receptors expressed on terminals of C-fibers in the spinal dorsal horn