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In terms of intervention, aerobic exercise upregulates LONP1 and mitochondrial-encoded genes in aged mouse skeletal muscle, ameliorating mitochondrialnuclear signaling imbalance and activating the UPRmt, indicating that exercise may improve muscle dysfunction in aging or pathological states by enhancing LONP1 expression or activity [136]

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Benefits may include improved sleep quality, faster recovery, better body composition, increased energy, and enhanced fat metabolism

Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial