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Forty RCTs that aligned with the PICO-SD criteria were selected from the systematic review,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55 and two more RCTs were added after an updated search.56, 57 The participants of these studies included general adult smokers (n = 23), patients with psychiatric conditions (n = 5), patients with pulmonary disease (n = 3), cardiovascular disease (n = 2), and other populations (n = 9)

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Several authorities, including the World Health Organization, feel there is not enough evidence to recommend e-cigarettes for quitting smoking, and there are studies showing a decline in smoking cessation among dual users [22, 23]