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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

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In addition, two subtypes of neutrophils have been reported at least in murine tumor models: TGF-independent type 1 (N1) with antimicrobial functions, and TGF-dependent tumor-associated neutrophils (N2, TANs) possessing pro-tumor and proangiogenic functions [263, 264]