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For motivated patients, some services allow patient-specific direction so they can self-administer B at home (after training)

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Specific figures circulating on commercial sites could not be verified in peer-reviewed literature and directly conflict with the published consensus that no human trials have been conducted treat them as unverified

NICE and British Society for Haematology guidelines recommend: Initial treatment with hydroxocobalamin (the preferred form in the UK) via intramuscular injection For patients without neurological involvement: 1 mg IM three times a week for 2 weeks For patients with neurological involvement: 1 mg IM on alternate days until no further improvement Maintenance: 1 mg every 3 months for patients without neurological involvement