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A particularly concerning condition associated with these drugs is stomach paralysis, or gastroparesis, a chronic condition where the stomach takes longer to empty its contents and potentially leads to blockages, resulting in significant discomfort and potentially severe complications

doi: 10.1371/journal.pone.0087716 10 TseliosKKoumarasCUrowitzMBGladmanDD

Again, it is difficult to design a reasonable, cost-effective biomedical protocol without proper observation

This is of particular importance for defining the redox secretome as opposed to the proteome, given the much lower concentration of secreted proteins compared to intracellular proteins