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It has long been thought of as an unspecific degradation system to regenerate nutrients

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The three non-coded amino acid substitutions serve critical functions: Aib2 provides stability against dipeptidyl peptidase-4 degradation, Aib20 optimizes GIP receptor activity and pharmacokinetic properties, and alpha-methyl-L-leucine at position 13 enhances receptor binding selectivity[2]

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