glp 1 agonists moa GLP-1 and Anesthesia: Considerations and Cautions for CRNAs Current Insights, Advantages and Challenges

Schoenenberger and Monnier reported in the Proceedings of the National Academy of Sciences USA the isolation, sequence determination and synthesis of the active material, identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and demonstrated that intraventricular infusion of the synthetic compound in rabbits reproduced delta- and spindle-EEG enhancement under double-blind conditions (Schoenenberger & Monnier, 1977)

Used as a research tool to study IGF-receptor pathways

Samples were blocked with PBS containing 5% FBS and 0.1% Tween 20 for 1 h at room temperature and incubated with primary antibodies overnight at 4 C, followed by incubation with fluorescence-conjugated secondary antibodies for 2 hours at room temperature

It may be administered IV or by subcutaneous injection