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In the Phase 2 trial, starting at a lower dose (2 mg versus 4 mg) significantly reduced the incidence and severity of gastrointestinal adverse events without compromising weight-loss outcomes

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Adverse Effects and Black Box Warnings Fluoxetines most common side effects include (21): Insomnia Nausea Diarrhea Anorexia Dry mouth Headache Drowsiness Anxiety Nervousness Yawning Decreased libido Decrease arousal or lubrication Bruising Hyperhidrosis Weight gain or loss Decreased orgasm Muscle weakness Tremors Pharyngitis Less common adverse effects include (21): Bleeding Seizures Suicidal ideation and behaviors Especially in teenagers Most adverse effects will appear upon initiation of treatment and should fade with time

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