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Studies demonstrate low plasma levels of 25(OH)VD in humans with genetic mutation for VDBP or in VDBP-knockdown (KD) mouse models (19, 30, 52)

It is used to study growth hormone release, endocrine signaling, and metabolic regulation pathways

While Retatrutide increases energy expenditure through hormonal signaling, these compounds act at the mitochondrial and enzymatic levels, respectively