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Pickart's research group went on to demonstrate that the Cu(II) coordination geometry an N3O distorted square-planar pyramid was the operative pharmacophore: free GHK without copper retains only a fraction of the wound-healing and gene-modulating activity of the chelate.[1][2] Research framework Within the matrix-remodeling and tissue-repair peptide research domain, GHK-Cu is most directly compared with BPC-157 for parallel cytoprotection and angiogenic signaling, with TB-500 for actin-cytoskeleton-mediated wound dynamics, and with Thymosin alpha-1 for companion immunoregulatory crosstalk

Umweltwiss Schadst Forsch 19(3):68179 Weinshilboum R, Otterness D (1994) Sulfotransferase enzymes

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analyzed the IR spectra of 16 proteins, including three IDPs, acid casein, rennet casein, and salmine, and pointed out that presence of characteristic bands in the spectra of all the proteins studied suggest the important role that the hydrogen bond plays in protein structure (Buswell et al., 1940)