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Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GLP-1 - Glucagon-like peptide-1 OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Mounjaro) - marketed for diabetes Tirzepatide (Zepbound) - marketed for weight loss MECHANISM OF ACTION GLP-1 and GIP GLP-1 stands for "glucagon-like peptide-1," and GIP stands for "glucose-dependent insulinotropic polypeptide." GIP is also sometimes referred to as "gastric inhibitory polypeptide." GLP-1 and GIP are hormones secreted by specialized cells in the small intestine in response to food consumption

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STAT reported on Tuesday that Eli Lilly and the Food and Drug Administration offered the drug to the patient, who has refractory obesity, obstructive sleep apnea, and pulmonary hypertension, via the FDAs compassionate use program

Whether the additional glucagon receptor activity of retatrutide contributes to a higher rate of gastrointestinal side effects compared with GLP-1 monotherapy has not yet been established in head-to-head studies, and any such comparison should be interpreted cautiously