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However, caution should be taken in individuals with autism who are undermethylators by supporting methylation pathways concurrently, including raising systemic alkalinity, supplementing with SAMe, creatine, methionine, B12, TMG, and co-factors like magnesium and biotin

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All treatments are administered by licensed clinicians in a professional setting focused on comfort and safety

Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits